From Sydney:
Take the Great Western Highway through the Blue Mountains or follow the Bells Line of Road to Lithgow. The turn off for Mudgee is just past Lithgow (look out for sign and exit on your left). Allow about 3.5hours of drving time (maybe a little more in peak hours). visit to get your preferred directions.
From Newcastle:
Take the stunning and fully sealed Bylong Valley Way A 4 hour drive via Maitland, Denman and Sandy Hollow, turn at Sandy Hollow and experience the village of Bylong, Rylstone or Wollar before arriving in Mudgee. Alternatively, take the road via Merriwa and Ulan to Gulgong or Mudgee.         From Canberra:
5 hours via Yass, Cowra and Wellington or via Cowra and Bathurst or approximately 5 hours via the scenic The Tablelands Way  through Goublurn, Crookwell and Oberon to Bathurst, then Wattle Flat, Sofala and Mudgee. The road is fully sealed.         From Tamworth:
A 4 hour drive through beautiful countryside on the New England Highway via Scone, Muswellbrook, Denman and Merriwa, turn off the Golden Highway onto Ulan Road through Gulgong or Mudgee.